'Healthy' obese people still at higher risk of cardiovascular disease events than general population
People with metabolically healthy obesity (MHO) are clinically obese in terms of their body mass index (BMI) (more than 30 kg/m2), but do not have metabolic complications that usually come with obesity, such as abnormal blood fats, poor blood sugar control or diabetes, and high blood pressure. Whether MHO is associated with excess risk of cardiovascular disease (CVD) events is a subject of debate. Important limitations in the evidence to date include inconsistent definitions of metabolic health, inconsistent control for other factors (confounders), and small sample sizes. In this new study, the authors address these limitations in a large contemporary cohort , based on linked primary care electronic health records. The researchers used linked electronic health records from 1995 to 2015 in The Health Improvement Network (THIN) -- a large UK database of general practice records -- to assemble a cohort of 3.5 million individuals aged 18 years or older and initially free from CVD. To d...